ABCD

ABCD 2023 • The Biennial Congress of the Italian Association of Cell Biology and Differentiation

Paestum | Italy 21-23 September 2023

ABCD

ABCD 2023 • The Biennial Congress of the Italian Association of Cell Biology and Differentiation

Paestum | Italy 21-23 September 2023

ABCD

ABCD 2023 • The Biennial Congress of the Italian Association of Cell Biology and Differentiation

Paestum | Italy 21-23 September 2023

Paestum | Italy
21-23 September 2023

Pre-Congress Meeting

Paestum, Italy • 20-21 September 2023

Information

The pre-congress meeting is reserved for post-docs and Ph.D. students who are under 35 years at the date of the congress. Attendance will be limited to 100 participants.

Participation in the pre-congress meeting is reserved to post-docs and Ph.D. students who will attend and submit an abstract to the ABCD 2023 National Congress.

In case of oversubscription, acceptance will be decided by the organisers based on the quality of the presented abstracts.

Among the participants of the pre-congress meeting, twenty-two will be selected for oral presentations during the pre-congress meeting. All participants (including those selected for oral presentations) are still expected to present their posters at the ABCD 2023 National Congress.

There is no registration fee for the pre-congress meeting and for the pre-congress meeting dinner.

Fellowships will be available for post-docs and Ph.D. students accepted to attend the pre-congress meeting to help defray their lodging and travel costs.

Programme

Wednesday, 20 September

12:00-15:30

Arrival and Registration

15:30-16:15

Keynote Lecture

Sandra Schmid (San Francisco, CA, USA)
Navigating a Career in Biomedical Sciences

16:15-16:30

Filippo Burattin (Milan, Italy)
T cell quiescence is developmentally tuned by mTORC1/LINE1 regulatory axis

16:30-16:45

Federico Donà (Milan, Italy)
Tissue specific mechanisms maintain epithelial integrity upon division misorientation

16:45-17:00

Gorana Jendrisek (Milan, Italy)
Signaling circuitries regulating EGFR non-clathrin endocytosis

17:00-17:15

Rosaria Di Martino (Naples, Italy)
Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity

17:15-17:30

Michela Rossini (Padua, Italy)
Dynamic chemogenetic reporters to investigate organelle coupling

17:30-17:45

Claudia Palazzo (Rome, Italy)
Exosomes released by tumor cells mediate a new neuropilin-dependent mechanism of endothelial cell regulation

17:45-18:00

Utsa Bhaduri (San Giovanni Rotondo, FG, Italy)
Novel ciliary protein TRIM8 is a multifunctional workhorse during the course of mitosis

18:00-18:15

Flavia Martino (Turin, Italy)
Identification of the proximity biotinylation interactome of the RabGAP TBC1D22B reveals a cell adhesion signature

18:15-18:30

Martina Sette (L’Aquila, Italy)
The iron master regulator hormone hepcidin activates SOX2 transcription, promotes stemness, and influences DNA repair

18:45-19:00

Seema Grewal (Journal of Cell Science Editor)
Behind the scenes of scientific publishing

19:00-21:00

Dine with the Scientists

21:15-22:30

Round Table with Telmo Pievani

Thursday, 21 September

8:30-8:45

Chinmay Maheshwari (Novara, Italy)
BECLIN-1 splicing isoforms isolated and characterized for their functional role in autophagy in cancer cells

8:45-9:00

Maria Iavazzo (Pozzuoli, NA, Italy)
The role of SQSTM1 during the transcriptional induction of autophagy

9:00-9:15

Francesca Spinelli (Padua, Italy)
The role of mitochondrial cations homeostasis in the control of the inflammatory response

9:15-9:30

Martina Cusan (Padua, Italy)
Novel small molecule inhibitors of mitochondrial fission regulator Drp1

9:30-9:45

Vanessa Tolotto (Udine, Italy)
HDAC4 targeting in FBXW7 mutated CRC re-sensitizes cells to Oxaliplatin treatment

9:45-10:00

Elisa Costanzo (Palermo, Italy)
Developing liver spheroids as a model to investigate the role of colorectal-cancer derived small extracellular vesicles in metastatic niche establishment

10:00-10:15

Simona Ricciardi (Pozzuoli, NA, Italy)
Unravelling the role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle

10:15-11:00

Keynote Lecture

Tom Kirchhausen (Boston, MA, USA)

11:00-11:30

Coffee break

11:30-11:45

Davide Acquarone (Turin, Italy)
The chaperone protein Melusin counteracts muscle atrophy induced by cancer cachexia

11:45-12:00

Gaia Laurenzi (Rome, Italy)
The role of protein-kinase C theta (PKCθ) in ALS disease progression

12:00-12:15

Laura De Rosa (Naples, Italy)
Early dysregulation of endosomal pathway in Down syndrome: potential impact in neuropathogenesis

12:15-12:30

Roberta Romano (Lecce, Italy)
RILP interacts with TDP-43 and its downregulation in amyotrophic lateral sclerosis compromises the autophagy-lysosomal pathway

12:30-12:45

Carina Cojocaru (Candiolo, TO, Italy)
Semaphorin3A reprograms cancer-associated fibroblasts towards a novel cancer restraining phenotype in pancreatic ductal adenocarcinoma

12:45-13:00

Giuseppe Mancuso (Promega)
Realtime biology: getting closer to physiologichal results

13:00-13:15

Awarding of the "Luca Daveggio" prize

13:15-15:30

Free time until the beginning of ABCD Congress. Lunch boxes provided.

Sandra Schmid

Schmid’s highly collaborative laboratory at the Scripps Research Institute (1988-2012) and then UT Southwestern (2012-2020), applied cell and molecular biology, biochemistry, biophysics, structural biology, and quantitative live cell microscopy to define the molecular mechanisms underlying clathrin-mediated endocytosis; with particular focus on the paradigmatic fission GTPase, dynamin. Schmid’s work, published in over 170 articles and reviews, has been recognized by numerous awards, including her election to the National Academy of Sciences in 2020. She has held many leadership positions, including Chair of Cell Biology at Scripps (2001-2012) and UTSW (2012-2020); Founding Editor of Traffic and Editor-in-chief of MBoC (2004-2010) and President of the American Society for Cell Biology (2011). She currently serves as the inaugural Chief Scientific Officer of the Chan Zuckerberg Biohub, an independently funded biomedical research institute that partners with Stanford, UC San Francisco and Berkeley to understand the mechanisms underlying diseases and develop new technologies that can lead to actionable diagnostics and effective therapies.

Thomas Kirchhausen

Seeing is believing; visual observations are a vital part of scientific studies. They are also key to the communication of science to the public and the participation of the public in the importance of scientific research and we use them to transmit knowledge and interpretation.
Direct observation of molecular events in vivo is a key goal of contemporary microscopy. Three recently developed forms of optical microscopy available in our laboratory -- Lattice Light Sheet Microscopy (LLSM), Lattice Light Sheet Microscopy optimized with Adaptive Optics (AO-LLSM) and focused ion beam scanning electron microscopy (FIB-SEM) -- are poised to bridge the gap between molecules and cells, either as independent entities in culture, as components of organoids, or as components of living tissues. The richness and magnitude of the data over periods ranging from seconds to hours, create new challenges for obtaining quantitative representations of the observed dynamics and for deriving accurate and comprehensive models for the underlying mechanisms needed to address problems in cell physiology and vertebrate development.
Our research program combines these frontier optical-imaging modalities with Artificial Intelligence Deep and Machine Learning methods to examine cellular membrane remodeling processes exemplified by cell size regulation and organization of the ER during cell division, post mitotic formation of nuclear pores complexes, organelle biogenesis, generation of intraluminal vesicles in endosomes, endosomal traffic and endosomal escape, immune responsiveness, lipid homeostasis, cell-cell recognition, and the interaction dynamics of SARS-CoV-2 or other viruses with host cells during early stages of infection.

Telmo Pievani

Telmo Pievani (1970) is Full Professor at the Department of Biology, University of Padua, where he covers the first Italian chair of Philosophy of Biological Sciences since 2015. After Ph.D. researches in USA, he has been Professor of Philosophy of Science at the University of Milan Bicocca (2001-2012). Past President (2017-2019) of the Italian Society of Evolutionary Biology, he is Fellow of several academic Institutions and scientific societies. He is member of the editorial boards of Evolution: Education and Outreach, Evolutionary Biology, Rendiconti Lincei Sc. Fis. Nat., Nature Italy, Istituto Treccani, and the Italian edition of Scientific American. He is author of 322 publications, included several books: “Introduction to Philosophy of Biology” (Laterza, 2005); “The Theory of Evolution” (Il Mulino, 2010); “Born to Believe” (Codice Edizioni, 2008, with V. Girotto and G. Vallortigara); “The Unexpected Life” (Cortina Editore, 2011); “Homo sapiens. The Great History of Human Diversity” (Codice Edizioni, 2011, with L.L. Cavalli Sforza), “Introduction to Darwin” (Laterza, 2012); “The End of the World” (Il Mulino, 2012); “Freedom of migration” (Einaudi, 2016, with V. Calzolaio); “How we will be” (Codice Edizioni, 2016, with L. De Biase); “Imperfection. A natural history” (Cortina, 2019, MIT Press, 2022); “The Earth after us” (Contrasto, 2019; with F. Lanting’s photos), “Finitude” (Cortina, 2020); “Serendipity” (Cortina, 2021); “Nature is bigger than us” (Solferino, 2022). Fellow of the Scientific Board of science festivals in Italy, since 2014 he is fellow of the International Scientific Council of MUSE in Trento. He is Director of “Pikaia”, the Italian website dedicated to evolution (www.pikaia.eu). He is Director of the University of Padua web magazine, Il Bo LIVE (https://ilbolive.unipd.it). With Niles Eldredge, Ian Tattersall and Luigi Luca Cavalli-Sforza, he curated International science exhibitions. Author of books for children and theatre scientific shows, he collaborates with RAI radio and TV projects, he is a columnist for Il Corriere della Sera, and the magazines Le Scienze and Micromega. Personal website: www.telmopievani.com