13:00-15:30 |
Registration and poster set-up |
15:30-15:45 |
Welcome and Opening of the Congress |
15:45-16:00 |
Remembering Tullio Pozzan Rosario Rizzuto, Padua, Italy |
16:00-16:45 |
Keynote Lecture Chairs: Letizia Lanzetti (Candiolo), Sara Sigismund (Milan) Andrea Ballabio, TIGEM, Naples, Italy |
16:45-18:15 |
Session 1 • Mechanism of eukaryotic cell shape Chairs: Letizia Lanzetti (Candiolo), Sara Sigismund (Milan) Giorgio Scita, University of Milan and IFOM, Italy Aurelien Roux, University of Geneva, Switzerland Sirio Dupont, University of Padua, Italy |
18:15-19:00 |
The EMBO Keynote Lecture Chair: Tom Kirchausen (Boston, MA, USA) Johanna Ivaska, University of Turku, Finland |
19:00-21:00 |
Poster Session 1 with refreshments |
21:00-22:30 |
Buffet dinner |
9:00-9:45 |
Keynote Lecture Chair: Katia Cortese (Genoa) Francesco Cecconi, Danish Cancer Society Research Center, Copenhagen, Denmark |
9:45-11:15 |
Session 2 • Metabolic cell signaling in physiology and cancer Chairs: Sirio Dupont (Padua), Anna Maria Porcelli (Bologna) Katja Simon, University of Oxford, United Kingdom Christian Frezza, CECAD, Cologne, Germany Nico Mitro, University of Milan, Italy |
11:15-12:00 |
Keynote Lecture Chair: Massimo Bonora (Ferrara) Anna Kajaste-Rudnitski, HSR, Milan, Italy |
12:00-16:00 |
Excursion to the temples and lunch box |
16:15-17:45 |
Session 3 • Pluripotency and morphogenesis Chairs: Marina Mapelli (Milan), Gabriella Minchiotti (Naples) Nuria Montserrat, IBEC, Barcelona, Spain Stephanie Ellis, Max Perutz Labs, Vienna, Austria Kim Jensen, University of Copenhagen, Denmark |
17:45-19:05 |
Science Dissemination and Technology Chair: Sandra Schmid (San Francisco, CA, USA) |
17:45-18:05 |
Seema Grewal, Journal of Cell Science Editor |
18:05-18:20 |
Antonello Cutolo, University of Naples Federico II, Italy |
18:20-18:35 |
Stefano Gabriele, Market Specialist HDx, Agilent Technologies Inc |
18:35-18:50 |
Andrea Cristaldi, Senior R&D and Application Specialist @CellDynamics, Twin Helix |
18:50-19:05 |
Sergio Braglia, Application Specialist Revvity Italia spa |
19:10-21:00 |
Poster Session 2 with refreshments |
21:00-22:30 |
Buffet dinner |
9:00-9:45 |
The Fondazione Umberto Veronesi Keynote Lecture Chair: Andrea Ballabio (Naples) Tobias Walther, Sloan Kettering Institute, New York, USA |
9:45-11:00 |
Session 4 • Frontiers in neurobiology Chairs: Antonio Musarò (Rome), Paola Pizzo (Padua) Keynote Na Ji, University of California Berkeley, CA, USA Cordelia Imig, University of Copenhagen, Denmark |
11:00-11:30 |
Coffee break |
11:30-12:15 |
Keynote Lecture Chairs: Giulia Piaggio (Rome), Giacomo Donati (Turin) Francesco Nicassio, IIT, Milan, Italy |
12:15-13:15 |
Session 5 • RNA biology Chairs: Giulia Piaggio (Rome), Giacomo Donati (Turin) Cristian Bellodi, Lund University, Sweden Stefano Biffo, INGM, Milan, Italy |
13:15-13:30 |
Official closure of the meeting |
13:30-15:00 |
Lunch |
15:00-18:00 |
Parallel Sessions: |
Session 1 • Cell structure and function (signaling, metabolism, organelles, trafficking, etc)
Chairs: Barbara Belletti (Aviano), Simona Paladino (Naples)
Anna Nespolo, Aviano, Italy
Targeting the deubiquitinase USP1 to improve PARP inhibitors response in ovarian cancer
Maria Chiara De Santis, Turin, Italy
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer
Giuseppe Giannini, Rome, Italy
Exploiting the STING pathway in MYCN amplified neuroblastoma
Carlo Cosimo Campa, Turin, Italy
Mapping biochemical motifs on the surface of a single endosome using FRET imaging and correlation analysis
Paolo Maiuri, Naples, Italy
Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis
Thomas Vaccari, Milan, Italy
Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells
Andrea Conte, Naples, Italy
Synpatojanin 1 (SYNJ1) dysfunction leads to autophagy dysregulation: potential impact on Parkinson’s disease
Giorgia Federico, Naples, Italy
Unveiling NCOA4 role in ferroptosis
Rossella Venditti, Naples, Italy
Distinct changes in endosomal composition promote NLRP3 inflammasome activation
Patrizia Romani, Padua, Italy
Mitochondria as a unifying hub coordinating metabolism and nuclear gene expression in response to ECM mechanics
Session 2 • Cell communication, development, regeneration and diseases
Chairs: Massimo Gulisano (Catania), Cristina Mazzoni (Rome), Graziano Martello (Padua)
Graziano Martello, Padua, Italy
Esrrb guides naive pluripotent cells through the formative transcriptional programme
Annalisa Fico, Naples, Italy
Symmetry breaking enable stem cell pluripotency exit during mouse gastruloid development
Marina Mapelli, Milan, Italy
Dissecting the molecular mechanisms of Wnt3-dependent oriented cell divisions
Alessandro Fiorenzano, Naples, Italy
Single cell sequencing and retrograde barcode tracing links molecular identities of human dopamine neurons to projection patterns in stem cell-derived grafts
Anna Urciuolo, Padua, Italy
Native extracellular matrix support human neuromuscular organoid morphogenesis and function
Elena Astanina, Candiolo, Italy
Transcription factor EB (TFEB) orchestrates cellular differentiation both in development and cancer
Lucia Di Marcotullio, Rome, Italy
ERAP1 is an emerging therapeutic target for Hedgehog-dependent medulloblastoma
Giulia Piaggio, Rome, Italy
Deciphering the crosstalk between miR-200C and NF-YA splicing in cancer cells
Alessandro Fatica, Rome, Italy
Enhancing sensitivity of triple negative breast cancer to DNA damaging therapy through chemical inhibition of the m6A methyltransferase METTL3
Samuele Maturi, Trento, Italy
Telomere dysfunction in autism spectrum disorders: hints from CHD8 haploinsufficiency
18:15-19:30 |
ABCD Assembly (members only) |
20:30 |
Social dinner |
Poster presenters are required to be available for discussion during their assigned session. Odd-numbered posters are pesented in the first session while even-numbered ones during the second session.
All posters should stay up for the entire duration of the meeting, independently of the session to which they have been assigned. You are kindly invited to put up your poster upon arrival, from Thursday at 15:00 onwards, and in time for the first poster session. Posters should be taken down before 18:00 on Saturday, 23 September.
When preparing your poster please remember that the poster's maximum size is A0 (841 x 1189 mm; width x height).
Correct format... 
Wrong format...
P.A1 • Ilenia Agliarulo • Naples
Broader insights into the palmitoylation process regulation: a role for the Golgi matrix protein GRASP55
P.A3 • Francesca Romana Auciello • Rome
Pancreatic adenocarcinoma (PDAC) macroenvironment before tumour appearance: new approaches to identify early tumour biomarkers
P.A5 • Matteo Balestra • Milan
The role of RNA and RNA-binding proteins in EGFR non-clathrin endocytosis and its relevance in physiological contexts
P.A7 • Doruk Bayburtlu • Pavia
Optimising the isolation of functional nuclei to study nuclear - mitochondria communication
P.A9 • Andrea Francesco Benvenuto • Milan
Role of Epsin3-mediated E-Cadherin endocytosis in partial EMT, breast cancer cell invasion and metastasis
P.A11 • Utsa Bhaduri • San Giovanni Rotondo
Novel ciliary protein TRIM8 is a multifunctional workhorse during the course of mitosis
P.A13 • Chiara Brignola • Naples
Impact of ribosomal protein uL3 status on cystine/glutamate antiporter xCT expression
P.A15 • Roberta Cacciatore • Milan
Molecular and structural investigation of the p53 regulatory pathway mediated by the Numb isoforms
P.A17 • Emanuela Cascone • Naples
Stem cell-based disease model of hepatic organoids to study the cellular phenotype of ATP7B mutant genotype
P.A19 • Manuela Cipolletti • Rome
The metabolic protein PMM2 depletion reduces ERα levels and cell proliferation in ESR1 Y537S mutant metastatic breast carcinoma cells
P.A21 • Filippo Conca • Pavia
Investigating the basis of nuclear PKA
P.A23 • Katia Cortese • Genoa
Neratinib is a TFEB and TFE3 activator that potentiates autophagy and unbalances energy metabolism in ERBB2+ breast cancer cells
P.A25 • Sara Cozzubbo • Turin
miR-214 induces cell metabolism rewiring which leads to tumor progression
P.A27 • Massimo D'Agostino • Naples
A delayed endoplasmic reticulum translocation defines spatiotemporal control of PD-L1 expression
P.A29 • Agnese De Mario • Padua
Exploring the role of mitochondrial Calcium uniporter in cancer
P.A31 • Anisa Degjoni • Rome
Ascertaining the role of Phosphodiesterase 5 in the regulation of Bisphenol A-induced
metabolic alterations
P.A33 • Mariagrazia Di Gennaro • Caserta
Unravelling the role of the TGN export machinery for basolateral proteins in Amyloid Precursor Protein (APP) transport and processing
P.A35 • Giuseppina Divisato • Naples
Sorbitol dehydrogenase deficiency impairs mitochondrial homeostasis in patients affected by CMT2/dHMN
P.A37 • Antonietta Fazio • Bologna
Exploring the impact of pericytes on muscle regeneration in COL6-related myopathies
P.A39 • Alessandra Ferraresi • Novara
Phenoconversion and pro-tumorigenic phenotype of cancer-associated fibroblasts rely on glucose-dependent inhibition of autophagy
P.A41 • Marianna Fico • Pozzuoli
PITPNC1 fuels lysosomes with phosphoinositides
P.A43 • Sinforosa Gagliardi • Lecce
Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells
P.A45 • Paloma García Casas • Padua
Ca2+-mediated regulation of ER-mitochondria contacts revealed by new dynamic chemogenetic reporters based on splitFAST
P.A47 • Ambra Maria Pia Gavillucci • Rome
Clock gene in NSCLC patients treated with immune checkpoint inhibitors
P.A49 • Simone Graziosi • Rome
Illuminating the dark side of the phosphoproteome
P.A51 • Aymone Gurtner • Rome
Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex
P.A53 • Maria Iavazzo • Pozzuoli
The role of SQSTM1 during the transcriptional induction of autophagy
P.A55 • Antonella Izzo • Naples
Neural precursor cells derived from trisomic iPSC show mitochondrial dysfunction and impaired mitochondrial quality control mechanisms
P.A57 • Housen Kacem Ben Haj M'Barek • L'Aquila
Crosstalk between inflammation and insulin resistance: therapeutic effect of IL-8 receptor inhibition in an in vitro model
P.A59 • Gianmaria Leone • Naples
Dissecting and piloting the intracellular trafficking of AAVs
P.A61 • Chinmay Maheshwari • Novara
BECLIN-1 splicing isoforms isolated and characterized for their functional role in autophagy in cancer cells
P.A63 • Flavia Martino • Candiolo (TO)
Identification of the proximity biotinylation interactome of the RabGAP TBC1D22B reveals a cell adhesion signature
P.A65 • Danilo Matassa • Naples
Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins
P.A67 • Giorgia Miloro • Milan
Screening of tethering factors affecting inter-organelle contact sites in EGFR non clathrin endocytosis (NCE)
P.A69 • Alessandra Murabito • Turin
A PI3Kγ mimetic peptide promotes F508del-CFTR plasma membrane stabilization through protein kinase D1 (PKD1)
P.A71 • Pampa Pain • Padua
The role of mitochondrial cations in the mtDNA release from mitochondria upon inflammation
P.A73 • Carlotta Paoli • Padua
Mitochondrial cristae remodeling promotes pancreatic tumorigenesis
P.A75 • Francesca Romana Pellegrini • Rome
ATAT1, α-Tubulin N-acetyltransferase 1, promotes autophagy and oxidative stress in non-small cell lung cancer cell lines
P.A77 • Ilaria Piazza • Padua
Altered intracellular Ca2+ homeostasis underlies castration-induced skeletal muscle atrophy
P.A79 • Maria Elena Pisanu • Rome
Integrating multi-omics-based approaches to discover novel immune-metabolic features of ovarian cancer patients’ ascites associated with treatment response
P.A81 • Elia Ranzato • Alessandria
The Achilles heel of mesothelioma targeted by the anticancer ruthenium drug BOLD-100
P.A83 • Simona Ricciardi • Pozzuoli
Unravelling the role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle
P.A85 • Michela Rossini • Padua
Dynamic chemogenetic reporters to investigate organelle coupling
P.A87 • Deborah Salvi Mesa • Milan
A multi-organelle platform regulates EGFR endocytosis and signaling
P.A89 • Miriana Sbrissa • Padua
Impact of ETC complex I dysfunction on mitochondrial Ca2+ homeostasis
P.A91 • Elisa Setten • Candiolo (TO)
Development and characterization of a TFEB quantity-dependent system capable to activate different cellular transcription programs
P.A93 • Irene Taddei • Rome
Characterization of a novel interplay between tyrosine kinases and NRF2 in cancer
P.A95 • Gloria Terriaca • Rome
SMURF proteins are negative modulators of the Hedgehog pathway
P.A97 • Elisa Maria Turco • Foggia
Retinoic acid-induced 1 gene haploinsufficiency causes autophagy defects and alters lipid metabolism in Smith-Magenis syndrome
P.A99 • Letizia Vallino • Novara
IL-6 promotes ovarian cancer cell migration via glycolysis-mediated inhibition of autophagy: counteracting effect of resveratrol
P.A101 • Fabrizia Zevolini • Siena
The ciliogenesis protein IFT20 promotes lytic granule biogenesis in cytotoxic T cells through the master lysosome regulator TFEB
P.B1 • Filippo Acconcia • Rome
Characterization of a new ERα mutation expressed in metastatic breast cancer patients and resistant to endocrine therapy drugs
P.B3 • Federica Amoruso • Milan
Exploring chd7 and sema interactions to identify novel pharmacological targets for the treatment of CHARGE syndrome
P.B5 • Mariaconcetta Augusto • Rome
A new function of the MRN complex in the regulation of primary ciliogenesis
P.B7 • Chiara Barzan • Pavia
A novel post-transcriptional circuit required for tumor angiogenesis and cancer growth
P.B9 • Marika Berardini • Rome
Microgravity effects on testicular physiology: study of enzymatic and hormonal parameters in mouse embryonic testis
P.B11 • Caterina Boccia • Rome
Targeting IL-6 signaling for the stabilization of skeletal muscle in DMD disease
P.B13 • Virginia Brancato • Milan
Patient-derived organoids as tool to investigate tumor heterogeneity in triple negative breast cancer
P.B15 • Daniela Capello • Novara
Colorectal cancer cells induce metabolic reprogramming in adipose-derived mesenchymal stem cells
P.B17 • Giuseppina Caretti • Milan
Identifying regulatory mechanisms of the methylase SMYD3 in breast cancer stem cells
P.B19 • Elena Casarotto • Milan
The impairment of the protein quality control system affects extracellular vesicles miRNA secretion in cellular models of TDP-43 proteinopathies
P.B21 • Marcella Cesana • Pozzuoli
TFEB is a master regulator of syncytiotrophoblast formation in the placenta
P.B23 • Angelita Costantino • Catania
Development of a patient-derived organoid (PDOs) technological platform for the functional testing of nutraceutical-based molecules
P.B25 • Anna Di Matteo • Pavia
NOVA2 upregulation plays a pervasive role in alternative splicing changes of gastric cancer endothelium
P.B27 • Giacomo Donati • Turin
Tissue memory relies on stem cell priming in distal undamaged areas
P.B29 • Alessandro Fantin • Milan
Endothelial cell-driven CXCR4 signalling limits vascular expansion during embryonic development in an organ-specific manner
P.B31 • Margherita Ferretti • Rome
Immune tolerance processes in endometrial cancer and aberrant pregnancy: potential target for diagnosis and therapy
P.B33 • Francesca Furone • Naples
Intestinal organoids from human stem cells: a good model to study Celiac Disease?
P.B35 • Ombretta Guardiola • Naples
Cripto-based micro-heterogeneity of muscle satellite cells enables adaptive response to regenerative micro-environment
P.B37 • Eduardo Ibello • Naples
Three-dimensional growth sensitizes pancreatic ductal adenocarcinoma cells to the anti-asthmatic budesonide
P.B39 • Francesca Liccardo • Rome
Retinoic acid and proteotoxic stress induce AML cell death overcoming bone marrow stromal cell protection
P.B41 • Marco Loria • Palermo
Horizontal transfer of long non-coding RNA H19 transports splicing factors in recipient cells
P.B43 • Marianna Maddaluno • Pozzuoli
ER-storage response to protein misfolding activates ER-phagy Fam134b transcriptional induction
P.B45 • Emanuele Middonti • Candiolo (TO)
The Neuroligin-2 / YAP axis regulates the progression of pancreatic intraepithelial neoplasia
P.B47 • Rosa Molfetta • Rome
SCF and IL-33 regulate mouse mast cell plasticity during colorectal cancer progression
P.B49 • Shirin Navacci • Rome
SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma
P.B51 • Alessandra Palazzi • Naples
Functional loss of HIPK2 alters TDP-43 subcellular localization: a new potential mechanism of amyotrophic lateral sclerosis (ALS) pathogenesis
P.B53 • Andrea Pelliccia • Rome
Androgen deprivation freezes hormone-sensitive prostate cancer cells in a reversible quasi-apoptotic state (QUAPS) stabilized by PARP and 5-LOX, which thus become unexpected therapeutic targets
P.B55 • Pietro Poggio • Turin
Loss of the HSP90 co-chaperone Morgana induces DNA damage and impairs cell proliferation in adult mouse tissues
P.B57 • Lucia Renzullo • Turin
Extracellular nucleophosmin1 promotes breast cancer progression
P.B59 • Claudia Ruscetta • Rome
Semaphorin regulation by miRNAs in ovarian cancer cells
P.B61 • Silvia Sozzi • Rome
HIPK2 role in the pathogenesis of liver fibrosis
P.B63 • Raffaele Strippoli • Rome
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on both α5β1-integrin mediated actin cytoskeleton and extracellular matrix protein remodeling
P.B65 • Chiara Tordonato • Milan
Development of quality-controlled biobank of patient-derived organoids to study breast cancer heterogeneity
P.B67 • Mariam Zouhair • Rome
In vitro modelling of cancer cachexia using a 3D skeletal muscle construct as a drug-screening tool to identify novel therapeutic approaches
P.C1 • Alberto Benetollo • Padua
LGMDR3 and CFTR corrector C17: pharmacological profile and efficacy
P.C3 • Marianna Ciotola • Naples
LAMC2-expressing cells drive pancreatic cancer progression and metastasis
P.C5 • Carina Cojocaru • Candiolo (TO)
Semaphorin3A reprograms cancer-associated fibroblasts towards a novel cancer restraining phenotype in pancreatic ductal adenocarcinoma
P.C7 • Davide Costabile • Naples
DNA methylation dynamics in single clones: an oscillating deterministic phenomenon
P.C9 • Francesco Dalla Barba • Padua
Modeling sarcoglycanopathy in zebrafish: a new tool for phenotype-based drug screening
P.C11 • Eleonora Di Venere • Naples
A cellular model of human podocytes to dissect the heterozygous pathogenic variants of TRIM8 gene in the FSGSNEDS
P.C13 • Martina La Spina • Padua
Rewiring of amino acid metabolism in Neurofibromatosis type 1-related tumors
P.C15 • Luigia Meo • Fisciano (SA)
Let‑7 microRNAs control the ceRNA uPAR-mRNA
P.C17 • Noemi Monti • Rome
Fish embryo extracts trigger tumor reversion by inhibiting the invasiveness and migration in breast cancer cells
P.C19 • Bianca Natiello • Rome
Uncovering the molecular mechanism governing Pin1-WWP2 antagonistic interplay on Notch3 in Ovarian Cancer
P.C21 • Martina Paladino • Naples
CRISPR-Cas9 based approaches to switch-off AAV transgene expression and eliminate episomal genome
P.C23 • Marialaura Petroni • Rome
Primary ciliogenesis or NBS1 localization at the centrosome/basal body are not affected by clastogenic drugs-induced DNA damage response
P.C25 • Valentina Schiano • Pozzuoli
Caulerpin: a natural compound enhancing autophagy and lysosomal biogenesis
P.C27 • Sara Zirpoli • Naples
MAPK cascade inhibitors cooperate with SHP2 blockade in anaplastic thyroid carcinoma (ATC) cells
P.A2 • Salwa Amreen • Novara
BECLIN-1-dependent autophagy inversely correlates with BCL-2 expression and predicts better prognosis in diffuse large B-cell lymphoma
P.A4 • Miriam Aurilia • Pozzuoli
High-content imaging approaches to identify new druggable targets to tackle Batten disease
P.A6 • Giovanna Bastari • Rome
Intracellular and extracellular neuroglobin in neural response to endoplasmic reticulum stress: implications for neurodegenerative diseases
P.A8 • Claudia Bellomo • Naples
Intestinal organoids as a model to study the role of PTPRK, an EGFR phosphatase, in celiac disease
P.A10 • Ambra Bertocco • Padua
Untangling the role of ER stress and membrane lipid imbalance in fine particulate matter exposure
P.A12 • Concetta Bianco • Pozzuoli
Function and regulation of Endoplasmic Reticulum-Golgi membrane contact sites during mitosis
P.A14 • Filippo Burattin • Milan
T cell quiescence is developmentally tuned by mTORC1/LINE1 regulatory axis
P.A16 • Giulia Calconi • Rome
ATM gene editing by CRISPR/Cas9 to validate the p53 mitotic centrosome localization as a functional test to predict pathogenicity of ATM VUS
P.A18 • Laura Cinque • Naples
FGF controls lysosome biogenesis in chondrocytes
P.A20 • Antonino Colanzi • Naples
The Golgi checkpoint: Golgi unlinking during G2 is required for correct spindle formation and cytokinesis
P.A22 • Aurora Cordaro • Palermo
The long non-coding RNA H19 regulates alternative splicing in colorectal cancer
P.A24 • Mattia Costanzo • Naples
Targeting bioactive lipids in gastrointestinal cancer: a study on the possible cross-talk between pro-resolving lipid mediators and endocannabinoid system
P.A26 • Martina Cusan • Padua
Novel small molecule inhibitors of mitochondrial fission regulator Drp1
P.A28 • Donato D'Angelo • Padua
Unravelling the role of CLPB in mitochondrial calcium homeostasis
P.A30 • Laura De Rosa • Naples
Early dysregulation of endosomal pathway in Down syndrome: potential impact in neuropathogenesis
P.A32 • Annamaria Di Fiore • Rome
Characterization of the mechanisms involved in KCASH oncosuppressors regulation
P.A34 • Rosaria Di Martino • Naples
Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity
P.A36 • Andrea Esposito • Novara
Resveratrol contrasts IL-6-driven ovarian cancer cell growth by inducing autophagy-mediated cancer cell dormancy: involvement of miR-1305, a novel oncomiRNA
P.A38 • Giulia Federici • Rome
p53 mitotic centrosome localization as a functional test to predict pathogenicity of ATM VUS
P.A40 • Diego Ferreri • Rome
dDoublecortin: pulling the strings from the darkness
P.A42 • Lorenzo Franci • Siena
MAPK15 supports lung cells to manage oxidative stress and cellular senescence by multiple and cooperating mechanisms
P.A44 • Beatrice Garavaglia • Novara
Butyrate-induced autophagy degradation of β–catenin results in the inhibition of colorectal cancer cell proliferation regardless of APC and β–catenin mutational status
P.A46 • Deborah Gargano • Pesche (IS)
Deciphering autophagy role in Glioblastoma biology
P.A48 • Michele Ginesi • Milan
Mathematical modeling of EGFR trafficking
P.A50 • Paolo Grumati • Pozzuoli
FAM134A,B,C: The Three Musketeers of ER-phagy
P.A52 • Francescopaolo Iavarone • Pozzuoli
A mTORC1-FAM134C axis controls starvation-induced ER-phagy and lipid metabolism in mouse liver
P.A54 • Angela Iuzzolino • Rome
Loss of ATAT1 induces mitotic defects in non-small cell adenocarcinoma cell lines
P.A56 • Gorana Jendrisek • Milan
Signaling circuitries regulating EGFR non-clathrin endocytosis
P.A58 • Konstantinos Lefkimmiatis • Pavia
Nuclear EPAC1 condensates: a new paradigm for cAMP-dependent transcription
P.A60 • Mariadomenica Lupi • Candiolo (TO)
Role of TBC1D7 in lipid metabolism in breast cancer cells
P.A62 • Vanessa Mancini • Rome
Contribution of TRPs in FGFR2 isoform switch-mediated oncogenic outcome
P.A64 • Simona Martinotti • Alessandria
Ca2+ signalling in primary corneal cells under umbilical cord platelet-rich plasma exposure
P.A66 • Loredana Migliore • Siena
The pro-autophagic protein AMBRA 1 regulates human cytotoxic T cell differentiation via phosphatase PP2A-dependent activation of the transcription factor TFEB
P.A68 • Valentina Mularoni • Modena
NF-YA promotes colorectal cancer aggressiveness through the regulation of glutamine biosynthesis
P.A70 • Flavia Ottavi • Rome
DDR2 orchestrates aggressive behavior of high-grade serous ovarian cancer cells
P.A72 • Francesca Palermo • Milan
Investigating the role of mitochondrial regulators in sorafenib and lenvatinib resistance in HCC cell line
P.A74 • Martina Parente • Rome
BET proteins: novel epigenetic modulators for Niemann-Pick disease
P.A76 • Rosa Pennisi • Candiolo (TO)
Unrevealing unconventional mTOR pathways and regulation in breast cancer
P.A78 • Martina Pinna • Rome
HL-1 cell line as in vitro model to study circadian rhythms in the heart
P.A80 • Lorenzo Prever • Turin
Phosphoinositides control over cytokinesis: PI4KA-loss in tetraploidy induction and breast cancer progression
P.A82 • Antonio Rea • Pozzuoli
TEX2 controls mitochondrial dynamics across ER-mitochondria contact sites
P.A84 • Roberta Romano • Lecce
RILP interacts with TDP-43 and its downregulation in amyotrophic lateral sclerosis compromises the autophagy-lysosomal pathway
P.A86 • Miriam Russo • Monteroduni
Lavender oil is a novel inhibitor of glioblastoma cell growth
P.A88 • Francesca Sardina • Rome
Spastin promotes cell motility and affects lipid behavior: implications in glioma treatments
P.A90 • Martina Sette • L'Aquila
The iron master regulator hormone hepcidin activates SOX2 transcription, promotes stemness, and influences DNA repair
P.A92 • Manuela Sollazzo • Bologna
SPARC and PKCα signaling activation upon CI-impairment in cancer models: a potential synthetic lethality approach
P.A94 • Simone Tealdi • Turin
Quantitative multiparametric image analysis to phenotipically profile internalization and recycling pathways
P.A96 • Marialuisa Testa • Pozzuoli
Identification of a novel role for OCRL in lipid droplet dynamics that contributes to the decline of kidney function in Lowe Syndrome
P.A98 • Sonia Valentini • Monterotondo
MDM2-MDM4 interaction interface imparts an otherwise therapeutically active wild-type p53 in colorectal cancer
P.A100 • Daniele Viavattene • Turin
mTOR involvement in STAT3 S-P at the ER and regulation of calcium-mediated apoptosis in TNBC
P.B2 • Davide Acquarone • Turin
The chaperone protein Melusin counteracts muscle atrophy induced by cancer cachexia
P.B4 • Francesco Argenton • Padua
More than development and growth: managing the zebrafish sandbox at the University of Padua
P.B6 • Stefania Bartoloni • Rome
Telaprevir: a novel modulator of ERα levels and antiproliferative agent in breast cancer cells
P.B8 • Sabrina Battista • Naples
The HMGA1/pNUMB axis as a potential link between diet and stem cell fate
P.B10 • Valeria Bica • Rome
In-depth phosphoproteomics reveals novel mechanisms of tyrosine kinase inhibitor resistance in chronic myeloid leukemia
P.B12 • Federica Borriello • Naples
Involvement of Lysophosphatidic acid receptor 4 (LPAR4)- dependent signaling in direct cardiac reprogramming
P.B14 • Michela Buonaiuto • Naples
A novel combination of drugs restrains glioblastoma growth in vitro and in vivo
P.B16 • Francesco Capradossi • Rome
5-lipoxygenase mediates etoposide-induced cancer repopulation and acquired cell-resistance (CRAC) in castration resistant prostate cancer cells
P.B18 • Claudia Carsetti • Rome
Cullin-4 inhibition works as a spastin-elevating approach in preclinical models of hereditary spastic paraplegia
P.B20 • Mariangela Cavallaro • Fisciano (SA)
Identifying epigenetic changes linked to activation of TBX1
P.B22 • Francesca Corsi • Rome
Cerium oxide nanozymes prevent prostate cancer relapse and progression by dismantling therapy-induced inflammatory COX-2/5-LOX lipid signalling
P.B24 • Elisa Costanzo • Palermo
Developing liver spheroids as a model to investigate the role of colorectal-cancer derived small extracellular vesicles in metastatic niche establishment
P.B26 • Federico Donà • Milan
Tissue specific mechanisms maintain epithelial integrity upon division misorientation
P.B28 • Carlotta Duval • Turin
Reciprocal screens ensure the identification of an epigenetic network for epithelial stem cell plasticity
P.B30 • Amir Fardin • Milan
The in vivo characterization of EPSIN 3 in breast cancer tumorigenesis and metastasis
P.B32 • Marco Fiocchetti • Rome
Functional role of the neuroprotective protein neuroglobin on differentiation and morphological phenotype of human neurons
P.B34 • Silvia Graziani • Padua
De novo mitochondrial DNA synthesis in senescent endothelial cells sustains sterile inflammation and doxorubicin cardiotoxicity
P.B36 • Alessia Iaiza • Rome
Role of m6A-dependent circRNAs during stress response in myeloid leukemia cells
P.B38 • Gaia Laurenzi • Rome
The role of protein-kinase C theta (PKCθ) in ALS disease progression
P.B40 • Giorgia Lombardozzi • L'Aquila
Protective effect of NGF in the diabetic retinopathy
P.B42 • Andrea Lunardi • Trento
Fire up innate immunity in prostate cancer
P.B44 • Vanessa Medici • Rome
Evaluation of the combined inhibition of alternative splicing and EZH2 activity as pro-immunogenic treatment for triple-negative breast cancers
P.B46 • Sonia Missiroli • Ferrara
PML at MAMs orchestrates signaling pathways IN- and OUT-side tumors
P.B48 • Giampaolo Morciano • Ferrara
A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients
P.B50 • Alyssa Paganoni • Milan
The Rho GTPases effector Rhotekin drives cytoskeletal dynamics tuning cortical development
P.B52 • Claudia Palazzo • Rome
Exosomes released by tumor cells mediate a new neuropilin-dependent mechanism of endothelial cell regulation
P.B54 • Silvia Piscitelli • Naples
The RNA-binding protein Lin28a orchestrates ESCs fate by changing partners during differentiation
P.B56 • Luca Ponzone • Turin
Rictor/mTORC2 downregulation promotes metabolic rewiring and therapeutic resistance in BRAFV600E melanoma cells
P.B58 • Maria serena Roca • Naples
Valproic Acid sensitizes colorectal cancer to chemotherapy by targeting cancer stem cell compartment through β-Catenin modulation
P.B60 • Federica Saracino • Naples
Dissecting the mechanisms underlying symmetry breaking and tissue-scale organization in colorectal cancer organoids
P.B62 • Francesca Spinelli • Padua
The role of mitochondrial cations homeostasis in the control of the inflammatory response
P.B64 • Claudia Tito • Rome
The role of Sorcin in the EGF-dependent EGFR signaling pathways in lung branching development and cancer
P.B66 • Marta Urbani • Rome
Modelling chemotherapy-induced Cancer Repopulation and Acquired Cell-resistance in prostate cells
P.C2 • Virginia Campani • Modena
The NF–Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer
P.C4 • Claudia Cirotti • Rome
NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
P.C6 • Giacomo Corleone • Rome
Uncovering the Role of NRF1/BRD3 axis as key mediators of Multiple Myeloma Progression
P.C8 • Antonello Cutolo • Naples
The CNOS center of nanophotonics for human health and a new teranostic platform: the hospital in the needle
P.C10 • Greta Deidda Tarquini • Rome
Cerium oxide nanoparticles protect human keratinocytes from UV-induced cell damage and oxidative stress and prevent mutagenesis
P.C12 • Ozlem Kartal • Padua
Targeting mitochondrial calcium and metabolism by RNA-based therapy in sarcopenia
P.C14 • Adriana Limone • Naples
Activation of non-canonical autophagic pathway through RPSA inhibition in neuronal cells: implications for neurodegenerative diseases
P.C16 • Sandro Montefusco • Pozzuoli
The TIGEM High Content Screening facility: Integrating advance technologies for investigating and treat genetic diseases
P.C18 • Lorena Musco • Aviano
Investigating the molecular diversity of luminal breast cancer arising in young women
P.C20 • Sabela Nikolli • Rome
Variations in the expression of DNA repair genes and in the expression of genes involved in oxidative stress used as biomarkers to identify the exposure to heavy metals
P.C22 • Monica Pastorino • Naples
The pesticide chlorpyrifos affects Npy and Agrp expression both in vivo and in vitro
P.C24 • Martina Scano • Padua
Repurposing CFTR correctors in Allan Herndon Dudley syndrome
P.C26 • Vanessa Tolotto • Udine
HDAC4 targeting in FBXW7 mutated CRC re-sensitizes cells to Oxaliplatin treatment