ABCD 2023 • The Biennial Congress of the Italian Association of Cell Biology and Differentiation

Paestum | Italy 21-23 September 2023


ABCD 2023 • The Biennial Congress of the Italian Association of Cell Biology and Differentiation

Paestum | Italy 21-23 September 2023


ABCD 2023 • The Biennial Congress of the Italian Association of Cell Biology and Differentiation

Paestum | Italy 21-23 September 2023

Paestum | Italy
21-23 September 2023


  • 13:00-15:30

    Registration and poster set-up


    Welcome and Opening of the Congress


    Remembering Tullio Pozzan

    Rosario Rizzuto, Padua, Italy


    Keynote Lecture

    Chairs: Letizia Lanzetti (Candiolo), Sara Sigismund (Milan)

    Andrea Ballabio, TIGEM, Naples, Italy
    Close encounters at the lysosomal surface


    Session 1 • Mechanism of eukaryotic cell shape

    Chairs: Letizia Lanzetti (Candiolo), Sara Sigismund (Milan)

    Giorgio Scita, University of Milan and IFOM, Italy
    Tissue fluidification in pathophysiology

    Aurelien Roux, University of Geneva, Switzerland
    In vitro reconstitution of membrane fission by ESCRT-III

    Sirio Dupont, University of Padua, Italy
    Links between tissue architecture and redox metabolism


    The EMBO Keynote Lecture

    Chair: Tom Kirchausen (Boston, MA, USA)

    Johanna Ivaska, University of Turku, Finland
    Cancer cells crossing borders


    Poster Session 1 with refreshments


    Buffet dinner

  • 9:00-9:45

    Keynote Lecture

    Chair: Katia Cortese (Genoa)

    Francesco Cecconi, Danish Cancer Society Research Center, Copenhagen, Denmark
    Selective autophagy and metabolic switches, the paradygm of social organelles


    Session 2 • Metabolic cell signaling in physiology and cancer

    Chairs: Sirio Dupont (Padua), Anna Maria Porcelli (Bologna)

    Katja Simon, University of Oxford, United Kingdom
    Autophagy in the healthy and aging immune system

    Christian Frezza, CECAD, Cologne, Germany
    Fumarate Hydratase and cancer: a paradigm of oncometabolism

    Nico Mitro, University of Milan, Italy
    Control of metabolism in hepatocellular carcinoma and breast cancer


    Keynote Lecture

    Chair: Massimo Bonora (Ferrara)

    Anna Kajaste-Rudnitski, HSR, Milan, Italy
    iPSC-based models to study the role of cell intrinsic innate immunity in disease and therapy


    Excursion to the temples and lunch box


    Session 3 • Pluripotency and morphogenesis

    Chairs: Marina Mapelli (Milan), Gabriella Minchiotti (Naples)

    Nuria Montserrat, IBEC, Barcelona, Spain
    From human pluripotent stem cells to model human disease: challenges and opportunities in organoid research

    Stephanie Ellis, Max Perutz Labs, Vienna, Austria
    Fighting with the neighbours: how cell competition shapes tissue dynamics in mammalian skin

    Kim Jensen, University of Copenhagen, Denmark
    Mechanisms of tissue regeneration


    Science Dissemination and Technology

    Chair: Sandra Schmid (San Francisco, CA, USA)


    Seema Grewal, Journal of Cell Science Editor
    An introduction to Journal of Cell Science and The Company of Biologists


    Antonello Cutolo, University of Naples Federico II, Italy
    The CNOS center of nanophotonics for human health and a new teranostic platform: the hospital in the needle


    Stefano Gabriele, Market Specialist HDx, Agilent Technologies Inc
    We share a common goal: working toward a life without cancer - Agilent Workflow for Oncology and Immunotherapy


    Andrea Cristaldi, Senior R&D and Application Specialist @CellDynamics, Twin Helix
    3D cell culture heterogeneity: what are we underestimating? A journey toward the biological relevance of biophysics


    Sergio Braglia, Application Specialist Revvity Italia spa
    Overcoming Western-Blot and ELISA with ALPHA and HTRF Technologies: Homogeneous Immuno-assay for fast and easy plate reader applications in cancer research


    Poster Session 2 with refreshments


    Buffet dinner

  • 9:00-9:45

    The Fondazione Umberto Veronesi Keynote Lecture

    Chair: Andrea Ballabio (Naples)

    Tobias Walther, Sloan Kettering Institute, New York, USA
    The phase of fat: mechanisms and physiology of lipid storage


    Session 4 • Frontiers in neurobiology

    Chairs: Antonio Musarò (Rome), Paola Pizzo (Padua)

    Keynote Na Ji, University of California Berkeley, CA, USA
    Imaging the brain at high spatiotemporal resolution

    Cordelia Imig, University of Copenhagen, Denmark
    Ready, steady, go! Dissecting key molecular organizers of regulated exocytosis in neurons and endocrine cells


    Coffee break


    Keynote Lecture

    Chairs: Giulia Piaggio (Rome), Giacomo Donati (Turin)

    Francesco Nicassio, IIT, Milan, Italy
    Interplay of coding and noncoding RNAs in cancer mechanisms


    Session 5 • RNA biology

    Chairs: Giulia Piaggio (Rome), Giacomo Donati (Turin)

    Cristian Bellodi, Lund University, Sweden
    Translation control by RNA pseudouridylation in stem and cancer cells

    Stefano Biffo, INGM, Milan, Italy
    Translational control of metabolism


    Official closure of the meeting




    Parallel Sessions:

    • Session 1 • Cell structure and function (signaling, metabolism, organelles, trafficking, etc)

      Chairs: Barbara Belletti (Aviano), Simona Paladino (Naples)

      Anna Nespolo, Aviano, Italy
      Targeting the deubiquitinase USP1 to improve PARP inhibitors response in ovarian cancer

      Maria Chiara De Santis, Turin, Italy
      Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer

      Giuseppe Giannini, Rome, Italy
      Exploiting the STING pathway in MYCN amplified neuroblastoma

      Carlo Cosimo Campa, Turin, Italy
      Mapping biochemical motifs on the surface of a single endosome using FRET imaging and correlation analysis

      Paolo Maiuri, Naples, Italy
      Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis

      Thomas Vaccari, Milan, Italy
      Novel determinants of NOTCH1 trafficking and signaling in breast epithelial cells

      Andrea Conte, Naples, Italy
      Synpatojanin 1 (SYNJ1) dysfunction leads to autophagy dysregulation: potential impact on Parkinson’s disease

      Giorgia Federico, Naples, Italy
      Unveiling NCOA4 role in ferroptosis

      Rossella Venditti, Naples, Italy
      Distinct changes in endosomal composition promote NLRP3 inflammasome activation

      Patrizia Romani, Padua, Italy
      Mitochondria as a unifying hub coordinating metabolism and nuclear gene expression in response to ECM mechanics

    • Session 2 • Cell communication, development, regeneration and diseases

      Chairs: Massimo Gulisano (Catania), Cristina Mazzoni (Rome), Graziano Martello (Padua)

      Graziano Martello, Padua, Italy
      Esrrb guides naive pluripotent cells through the formative transcriptional programme

      Annalisa Fico, Naples, Italy
      Symmetry breaking enable stem cell pluripotency exit during mouse gastruloid development

      Marina Mapelli, Milan, Italy
      Dissecting the molecular mechanisms of Wnt3-dependent oriented cell divisions

      Alessandro Fiorenzano, Naples, Italy
      Single cell sequencing and retrograde barcode tracing links molecular identities of human dopamine neurons to projection patterns in stem cell-derived grafts

      Anna Urciuolo, Padua, Italy
      Native extracellular matrix support human neuromuscular organoid morphogenesis and function

      Elena Astanina, Candiolo, Italy
      Transcription factor EB (TFEB) orchestrates cellular differentiation both in development and cancer

      Lucia Di Marcotullio, Rome, Italy
      ERAP1 is an emerging therapeutic target for Hedgehog-dependent medulloblastoma

      Giulia Piaggio, Rome, Italy
      Deciphering the crosstalk between miR-200C and NF-YA splicing in cancer cells

      Alessandro Fatica, Rome, Italy
      Enhancing sensitivity of triple negative breast cancer to DNA damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

      Samuele Maturi, Trento, Italy
      Telomere dysfunction in autism spectrum disorders: hints from CHD8 haploinsufficiency


    ABCD Assembly (members only)


    Social dinner

  • Poster presenters are required to be available for discussion during their assigned session. Odd-numbered posters are pesented in the first session while even-numbered ones during the second session.

    All posters should stay up for the entire duration of the meeting, independently of the session to which they have been assigned. You are kindly invited to put up your poster upon arrival, from Thursday at 15:00 onwards, and in time for the first poster session. Posters should be taken down before 18:00 on Saturday, 23 September.

    When preparing your poster please remember that the poster's maximum size is A0 (841 x 1189 mm; width x height).

    Correct format... poster should be PORTRAIT    poster should NOT be LANDSCAPE Wrong format...

    • Poster Session 1 • 21 September • 19:00-21:00

      P.A1 • Ilenia Agliarulo • Naples
      Broader insights into the palmitoylation process regulation: a role for the Golgi matrix protein GRASP55

      P.A3 • Francesca Romana Auciello • Rome
      Pancreatic adenocarcinoma (PDAC) macroenvironment before tumour appearance: new approaches to identify early tumour biomarkers

      P.A5 • Matteo Balestra • Milan
      The role of RNA and RNA-binding proteins in EGFR non-clathrin endocytosis and its relevance in physiological contexts

      P.A7 • Doruk Bayburtlu • Pavia
      Optimising the isolation of functional nuclei to study nuclear - mitochondria communication

      P.A9 • Andrea Francesco Benvenuto • Milan
      Role of Epsin3-mediated E-Cadherin endocytosis in partial EMT, breast cancer cell invasion and metastasis

      P.A11 • Utsa Bhaduri • San Giovanni Rotondo
      Novel ciliary protein TRIM8 is a multifunctional workhorse during the course of mitosis

      P.A13 • Chiara Brignola • Naples
      Impact of ribosomal protein uL3 status on cystine/glutamate antiporter xCT expression

      P.A15 • Roberta Cacciatore • Milan
      Molecular and structural investigation of the p53 regulatory pathway mediated by the Numb isoforms 

      P.A17 • Emanuela Cascone • Naples
      Stem cell-based disease model of hepatic organoids to study the cellular phenotype of ATP7B mutant genotype

      P.A19 • Manuela Cipolletti • Rome
      The metabolic protein PMM2 depletion reduces ERα levels and cell proliferation in ESR1 Y537S mutant metastatic breast carcinoma cells

      P.A21 • Filippo Conca • Pavia
      Investigating the basis of nuclear PKA

      P.A23 • Katia Cortese • Genoa
      Neratinib is a TFEB and TFE3 activator that potentiates autophagy and unbalances energy metabolism in ERBB2+ breast cancer cells

      P.A25 • Sara Cozzubbo • Turin
      miR-214 induces cell metabolism rewiring which leads to tumor progression

      P.A27 • Massimo D'Agostino • Naples
      A delayed endoplasmic reticulum translocation defines spatiotemporal control of PD-L1 expression

      P.A29 • Agnese De Mario • Padua
      Exploring the role of mitochondrial Calcium uniporter in cancer

      P.A31 • Anisa Degjoni • Rome
      Ascertaining the role of Phosphodiesterase 5 in the regulation of Bisphenol A-induced
      metabolic alterations

      P.A33 • Mariagrazia Di Gennaro • Caserta
      Unravelling the role of the TGN export machinery for basolateral proteins in Amyloid Precursor Protein (APP) transport and processing

      P.A35 • Giuseppina Divisato • Naples
      Sorbitol dehydrogenase deficiency impairs mitochondrial homeostasis in patients affected by CMT2/dHMN

      P.A37 • Antonietta Fazio • Bologna
      Exploring the impact of pericytes on muscle regeneration in COL6-related myopathies

      P.A39 • Alessandra Ferraresi • Novara
      Phenoconversion and pro-tumorigenic phenotype of cancer-associated fibroblasts rely on glucose-dependent inhibition of autophagy

      P.A41 • Marianna Fico • Pozzuoli
      PITPNC1 fuels lysosomes with phosphoinositides

      P.A43 • Sinforosa Gagliardi • Lecce
      Defects of mitochondria-lysosomes communication induce secretion of mitochondria-derived vesicles and drive chemoresistance in ovarian cancer cells

      P.A45 • Paloma García Casas • Padua
      Ca2+-mediated regulation of ER-mitochondria contacts revealed by new dynamic chemogenetic reporters based on splitFAST

      P.A47 • Ambra Maria Pia Gavillucci • Rome
      Clock gene in NSCLC patients treated with immune checkpoint inhibitors

      P.A49 • Simone Graziosi • Rome
      Illuminating the dark side of the phosphoproteome

      P.A51 • Aymone Gurtner • Rome
      Dysregulation of microRNA biogenesis in cancer: the impact of mutant p53/Dicer complex

      P.A53 • Maria Iavazzo • Pozzuoli
      The role of SQSTM1 during the transcriptional induction of autophagy

      P.A55 • Antonella Izzo • Naples
      Neural precursor cells derived from trisomic iPSC show mitochondrial dysfunction and impaired mitochondrial quality control mechanisms

      P.A57 • Housen Kacem Ben Haj M'Barek • L'Aquila
      Crosstalk between inflammation and insulin resistance: therapeutic effect of IL-8 receptor inhibition in an in vitro model

      P.A59 • Gianmaria Leone • Naples
      Dissecting and piloting the intracellular trafficking of AAVs

      P.A61 • Chinmay Maheshwari • Novara
      BECLIN-1 splicing isoforms isolated and characterized for their functional role in autophagy in cancer cells

      P.A63 • Flavia Martino • Candiolo (TO)
      Identification of the proximity biotinylation interactome of the RabGAP TBC1D22B reveals a cell adhesion signature

      P.A65 • Danilo Matassa • Naples
      Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins

      P.A67 • Giorgia Miloro • Milan
      Screening of tethering factors affecting inter-organelle contact sites in EGFR non clathrin endocytosis (NCE)

      P.A69 • Alessandra Murabito • Turin
      A PI3Kγ mimetic peptide promotes F508del-CFTR plasma membrane stabilization through protein kinase D1 (PKD1)

      P.A71 • Pampa Pain • Padua
      The role of mitochondrial cations in the mtDNA release from mitochondria upon inflammation

      P.A73 • Carlotta Paoli • Padua
      Mitochondrial cristae remodeling promotes pancreatic tumorigenesis

      P.A75 • Francesca Romana Pellegrini • Rome
      ATAT1, α-Tubulin N-acetyltransferase 1, promotes autophagy and oxidative stress in non-small cell lung cancer cell lines

      P.A77 • Ilaria Piazza • Padua
      Altered intracellular Ca2+ homeostasis underlies castration-induced skeletal muscle atrophy

      P.A79 • Maria Elena Pisanu • Rome
      Integrating multi-omics-based approaches to discover novel immune-metabolic features of ovarian cancer patients’ ascites associated with treatment response

      P.A81 • Elia Ranzato • Alessandria
      The Achilles heel of mesothelioma targeted by the anticancer ruthenium drug BOLD-100

      P.A83 • Simona Ricciardi • Pozzuoli
      Unravelling the role of NSP6 in the biogenesis of the SARS-CoV-2 replication organelle

      P.A85 • Michela Rossini • Padua
      Dynamic chemogenetic reporters to investigate organelle coupling

      P.A87 • Deborah Salvi Mesa • Milan
      A multi-organelle platform regulates EGFR endocytosis and signaling

      P.A89 • Miriana Sbrissa • Padua
      Impact of ETC complex I dysfunction on mitochondrial Ca2+ homeostasis

      P.A91 • Elisa Setten • Candiolo (TO)
      Development and characterization of a TFEB quantity-dependent system capable to activate different cellular transcription programs

      P.A93 • Irene Taddei • Rome
      Characterization of a novel interplay between tyrosine kinases and NRF2 in cancer

      P.A95 • Gloria Terriaca • Rome
      SMURF proteins are negative modulators of the Hedgehog pathway

      P.A97 • Elisa Maria Turco • Foggia
      Retinoic acid-induced 1 gene haploinsufficiency causes autophagy defects and alters lipid metabolism in Smith-Magenis syndrome

      P.A99 • Letizia Vallino • Novara
      IL-6 promotes ovarian cancer cell migration via glycolysis-mediated inhibition of autophagy: counteracting effect of resveratrol

      P.A101 • Fabrizia Zevolini • Siena
      The ciliogenesis protein IFT20 promotes lytic granule biogenesis in cytotoxic T cells through the master lysosome regulator TFEB

      P.B1 • Filippo Acconcia • Rome
      Characterization of a new ERα mutation expressed in metastatic breast cancer patients and resistant to endocrine therapy drugs

      P.B3 • Federica Amoruso • Milan
      Exploring chd7 and sema interactions to identify novel pharmacological targets for the treatment of CHARGE syndrome

      P.B5 • Mariaconcetta Augusto • Rome
      A new function of the MRN complex in the regulation of primary ciliogenesis

      P.B7 • Chiara Barzan • Pavia
      A novel post-transcriptional circuit required for tumor angiogenesis and cancer growth

      P.B9 • Marika Berardini • Rome
      Microgravity effects on testicular physiology: study of enzymatic and hormonal parameters in mouse embryonic testis

      P.B11 • Caterina Boccia • Rome
      Targeting IL-6 signaling for the stabilization of skeletal muscle in DMD disease

      P.B13 • Virginia Brancato • Milan
      Patient-derived organoids as tool to investigate tumor heterogeneity in triple negative breast cancer

      P.B15 • Daniela Capello • Novara
      Colorectal cancer cells induce metabolic reprogramming in adipose-derived mesenchymal stem cells

      P.B17 • Giuseppina Caretti • Milan
      Identifying regulatory mechanisms  of the methylase SMYD3 in breast cancer stem cells

      P.B19 • Elena Casarotto • Milan
      The impairment of the protein quality control system affects extracellular vesicles miRNA secretion in cellular models of TDP-43 proteinopathies

      P.B21 • Marcella Cesana • Pozzuoli
      TFEB is a master regulator of syncytiotrophoblast formation in the placenta

      P.B23 • Angelita Costantino • Catania
      Development of a patient-derived organoid (PDOs) technological platform for the functional testing of nutraceutical-based molecules

      P.B25 • Anna Di Matteo • Pavia
      NOVA2 upregulation plays a pervasive role in alternative splicing changes of gastric cancer endothelium

      P.B27 • Giacomo Donati • Turin
      Tissue memory relies on stem cell priming in distal undamaged areas

      P.B29 • Alessandro Fantin • Milan
      Endothelial cell-driven CXCR4 signalling limits vascular expansion during embryonic development in an organ-specific manner

      P.B31 • Margherita Ferretti • Rome
      Immune tolerance processes in endometrial cancer and aberrant pregnancy: potential target for diagnosis and therapy

      P.B33 • Francesca Furone • Naples
      Intestinal organoids from human stem cells: a good model to study Celiac Disease?

      P.B35 • Ombretta Guardiola • Naples
      Cripto-based micro-heterogeneity of muscle satellite cells enables adaptive response to regenerative micro-environment

      P.B37 • Eduardo Ibello • Naples
      Three-dimensional growth sensitizes pancreatic ductal adenocarcinoma cells to the anti-asthmatic budesonide

      P.B39 • Francesca Liccardo • Rome
      Retinoic acid and proteotoxic stress induce AML cell death overcoming bone marrow stromal cell protection

      P.B41 • Marco Loria • Palermo
      Horizontal transfer of long non-coding RNA H19 transports splicing factors in recipient cells

      P.B43 • Marianna Maddaluno • Pozzuoli
      ER-storage response to protein misfolding activates ER-phagy Fam134b transcriptional induction

      P.B45 • Emanuele Middonti • Candiolo (TO)
      The Neuroligin-2 / YAP axis regulates the progression of pancreatic intraepithelial neoplasia

      P.B47 • Rosa Molfetta • Rome
      SCF and IL-33 regulate mouse mast cell plasticity during colorectal cancer progression

      P.B49 • Shirin Navacci • Rome
      SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma

      P.B51 • Alessandra Palazzi • Naples
      Functional loss of HIPK2 alters TDP-43 subcellular localization: a new potential mechanism of amyotrophic lateral sclerosis (ALS) pathogenesis

      P.B53 • Andrea Pelliccia • Rome
      Androgen deprivation freezes hormone-sensitive prostate cancer cells in a reversible quasi-apoptotic state (QUAPS) stabilized by PARP and 5-LOX, which thus become unexpected therapeutic targets

      P.B55 • Pietro Poggio • Turin
      Loss of the HSP90 co-chaperone Morgana induces DNA damage and impairs cell proliferation in adult mouse tissues

      P.B57 • Lucia Renzullo • Turin
      Extracellular nucleophosmin1 promotes breast cancer progression

      P.B59 • Claudia Ruscetta • Rome
      Semaphorin regulation by miRNAs in ovarian cancer cells

      P.B61 • Silvia Sozzi • Rome
      HIPK2 role in the pathogenesis of liver fibrosis

      P.B63 • Raffaele Strippoli • Rome
      HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on both α5β1-integrin mediated actin cytoskeleton and extracellular matrix protein remodeling

      P.B65 • Chiara Tordonato • Milan
      Development of quality-controlled biobank of patient-derived organoids to study breast cancer heterogeneity

      P.B67 • Mariam Zouhair • Rome
      In vitro modelling of cancer cachexia using a 3D skeletal muscle construct as a drug-screening tool to identify novel therapeutic approaches

      P.C1 • Alberto Benetollo • Padua
      LGMDR3 and CFTR corrector C17: pharmacological profile and efficacy

      P.C3 • Marianna Ciotola • Naples
      LAMC2-expressing cells drive pancreatic cancer progression and metastasis

      P.C5 • Carina Cojocaru • Candiolo (TO)
      Semaphorin3A reprograms cancer-associated fibroblasts towards a novel cancer restraining phenotype in pancreatic ductal adenocarcinoma

      P.C7 • Davide Costabile • Naples
      DNA methylation dynamics in single clones: an oscillating deterministic phenomenon 

      P.C9 • Francesco Dalla Barba • Padua
      Modeling sarcoglycanopathy in zebrafish: a new tool for phenotype-based drug screening

      P.C11 • Eleonora Di Venere • Naples
      A cellular model of human podocytes to dissect the heterozygous pathogenic variants of TRIM8 gene in the FSGSNEDS

      P.C13 • Martina La Spina • Padua
      Rewiring of amino acid metabolism in Neurofibromatosis type 1-related tumors

      P.C15 • Luigia Meo • Fisciano (SA)
      Let‑7 microRNAs control the ceRNA uPAR-mRNA 

      P.C17 • Noemi Monti • Rome
      Fish embryo extracts trigger tumor reversion by inhibiting the invasiveness and migration in breast cancer cells

      P.C19 • Bianca Natiello • Rome
      Uncovering the molecular mechanism governing Pin1-WWP2 antagonistic interplay on Notch3 in Ovarian Cancer

      P.C21 • Martina Paladino • Naples
      CRISPR-Cas9 based approaches to switch-off AAV transgene expression and eliminate episomal genome

      P.C23 • Marialaura Petroni • Rome
      Primary ciliogenesis or NBS1 localization at the centrosome/basal body are not affected by clastogenic drugs-induced DNA damage response

      P.C25 • Valentina Schiano • Pozzuoli
      Caulerpin: a natural compound enhancing autophagy and lysosomal biogenesis

      P.C27 • Sara Zirpoli • Naples
      MAPK cascade inhibitors cooperate with SHP2 blockade in anaplastic thyroid carcinoma (ATC) cells

    • Poster Session 2 • 22 September • 19:10-21:00

      P.A2 • Salwa Amreen • Novara
      BECLIN-1-dependent autophagy inversely correlates with BCL-2 expression and predicts better prognosis in diffuse large B-cell lymphoma

      P.A4 • Miriam Aurilia • Pozzuoli
      High-content imaging approaches to identify new druggable targets to tackle Batten disease

      P.A6 • Giovanna Bastari • Rome
      Intracellular and extracellular neuroglobin in neural response to endoplasmic reticulum stress: implications for neurodegenerative diseases

      P.A8 • Claudia Bellomo • Naples
      Intestinal organoids as a model to study the role of PTPRK, an EGFR phosphatase, in celiac disease

      P.A10 • Ambra Bertocco • Padua
      Untangling the role of ER stress and membrane lipid imbalance in fine particulate matter exposure

      P.A12 • Concetta Bianco • Pozzuoli
      Function and regulation of Endoplasmic Reticulum-Golgi membrane contact sites during mitosis

      P.A14 • Filippo Burattin • Milan
      T cell quiescence is developmentally tuned by mTORC1/LINE1 regulatory axis

      P.A16 • Giulia Calconi • Rome
      ATM gene editing by CRISPR/Cas9 to validate the p53 mitotic centrosome localization as a functional test to predict pathogenicity of ATM VUS

      P.A18 • Laura Cinque • Naples
      FGF controls lysosome biogenesis in chondrocytes

      P.A20 • Antonino Colanzi • Naples
      The Golgi checkpoint: Golgi unlinking during G2 is required for correct spindle formation and cytokinesis

      P.A22 • Aurora Cordaro • Palermo
      The long non-coding RNA H19 regulates alternative splicing in colorectal cancer

      P.A24 • Mattia Costanzo • Naples
      Targeting bioactive lipids in gastrointestinal cancer: a study on the possible cross-talk between pro-resolving lipid mediators and endocannabinoid system

      P.A26 • Martina Cusan • Padua
      Novel small molecule inhibitors of mitochondrial fission regulator Drp1

      P.A28 • Donato D'Angelo • Padua
      Unravelling the role of CLPB in mitochondrial calcium homeostasis

      P.A30 • Laura De Rosa • Naples
      Early dysregulation of endosomal pathway in Down syndrome: potential impact in neuropathogenesis

      P.A32 • Annamaria Di Fiore • Rome
      Characterization of the mechanisms involved in KCASH oncosuppressors regulation

      P.A34 • Rosaria Di Martino • Naples
      Autoregulatory circuit regulating basolateral cargo export from the TGN: role of the orphan receptor GPRC5A in PKD signaling and cell polarity

      P.A36 • Andrea Esposito • Novara
      Resveratrol contrasts IL-6-driven ovarian cancer cell growth by inducing autophagy-mediated cancer cell dormancy: involvement of miR-1305, a novel oncomiRNA

      P.A38 • Giulia Federici • Rome
      p53 mitotic centrosome localization as a functional test to predict pathogenicity of ATM VUS

      P.A40 • Diego Ferreri • Rome
      dDoublecortin: pulling the strings from the darkness

      P.A42 • Lorenzo Franci • Siena
      MAPK15 supports lung cells to manage oxidative stress and cellular senescence by multiple and cooperating mechanisms

      P.A44 • Beatrice Garavaglia • Novara
      Butyrate-induced autophagy degradation of β–catenin results in the inhibition of colorectal cancer cell proliferation regardless of APC and β–catenin mutational status

      P.A46 • Deborah Gargano • Pesche (IS)
      Deciphering autophagy role in Glioblastoma biology

      P.A48 • Michele Ginesi • Milan
      Mathematical modeling of EGFR trafficking

      P.A50 • Paolo Grumati • Pozzuoli
      FAM134A,B,C: The Three Musketeers of ER-phagy

      P.A52 • Francescopaolo Iavarone • Pozzuoli
      A mTORC1-FAM134C axis controls starvation-induced ER-phagy and lipid metabolism in mouse liver

      P.A54 • Angela Iuzzolino • Rome
      Loss of ATAT1 induces mitotic defects in non-small cell adenocarcinoma cell lines

      P.A56 • Gorana Jendrisek • Milan
      Signaling circuitries regulating EGFR non-clathrin endocytosis

      P.A58 • Konstantinos Lefkimmiatis • Pavia
      Nuclear EPAC1 condensates: a new paradigm for cAMP-dependent transcription

      P.A60 • Mariadomenica Lupi • Candiolo (TO)
      Role of TBC1D7 in lipid metabolism in breast cancer cells

      P.A62 • Vanessa Mancini • Rome
      Contribution of TRPs in FGFR2 isoform switch-mediated oncogenic outcome

      P.A64 • Simona Martinotti • Alessandria
      Ca2+ signalling in primary corneal cells under umbilical cord platelet-rich plasma exposure

      P.A66 • Loredana Migliore • Siena
      The pro-autophagic protein AMBRA 1 regulates human cytotoxic T cell differentiation via phosphatase PP2A-dependent activation of the transcription factor TFEB

      P.A68 • Valentina Mularoni • Modena
      NF-YA promotes colorectal cancer aggressiveness through the regulation of glutamine biosynthesis

      P.A70 • Flavia Ottavi • Rome
      DDR2 orchestrates aggressive behavior of high-grade serous ovarian cancer cells

      P.A72 • Francesca Palermo • Milan
      Investigating the role of mitochondrial regulators in sorafenib and lenvatinib resistance in HCC cell line 

      P.A74 • Martina Parente • Rome
      BET proteins: novel epigenetic modulators for Niemann-Pick disease

      P.A76 • Rosa Pennisi • Candiolo (TO)
      Unrevealing unconventional mTOR pathways and regulation in breast cancer

      P.A78 • Martina Pinna • Rome
      HL-1 cell line as in vitro model to study circadian rhythms in the heart

      P.A80 • Lorenzo Prever • Turin
      Phosphoinositides control over cytokinesis: PI4KA-loss in tetraploidy induction and breast cancer progression

      P.A82 • Antonio Rea • Pozzuoli
      TEX2 controls mitochondrial dynamics across ER-mitochondria contact sites

      P.A84 • Roberta Romano • Lecce
      RILP interacts with TDP-43 and its downregulation in amyotrophic lateral sclerosis compromises the autophagy-lysosomal pathway

      P.A86 • Miriam Russo • Monteroduni
      Lavender oil is a novel inhibitor of glioblastoma cell growth

      P.A88 • Francesca Sardina • Rome
      Spastin promotes cell motility and affects lipid behavior: implications in glioma treatments

      P.A90 • Martina Sette • L'Aquila
      The iron master regulator hormone hepcidin activates SOX2 transcription, promotes stemness, and influences DNA repair

      P.A92 • Manuela Sollazzo • Bologna
      SPARC and PKCα signaling activation upon CI-impairment in cancer models: a potential synthetic lethality approach

      P.A94 • Simone Tealdi • Turin
      Quantitative multiparametric image analysis to phenotipically profile internalization and recycling pathways

      P.A96 • Marialuisa Testa • Pozzuoli
      Identification of a novel role for OCRL in lipid droplet dynamics that contributes to the decline of kidney function in Lowe Syndrome

      P.A98 • Sonia Valentini • Monterotondo
      MDM2-MDM4 interaction interface imparts an otherwise therapeutically active wild-type p53 in colorectal cancer

      P.A100 • Daniele Viavattene • Turin
      mTOR involvement in STAT3 S-P at the ER and regulation of calcium-mediated apoptosis in TNBC

      P.B2 • Davide Acquarone • Turin
      The chaperone protein Melusin counteracts muscle atrophy induced by cancer cachexia

      P.B4 • Francesco Argenton • Padua
      More than development and growth: managing the zebrafish sandbox at the University of Padua

      P.B6 • Stefania Bartoloni • Rome
      Telaprevir: a novel modulator of ERα levels and antiproliferative agent in breast cancer cells

      P.B8 • Sabrina Battista • Naples
      The HMGA1/pNUMB axis as a potential link between diet and stem cell fate

      P.B10 • Valeria Bica • Rome
      In-depth phosphoproteomics reveals novel mechanisms of tyrosine kinase inhibitor resistance in chronic myeloid leukemia

      P.B12 • Federica Borriello • Naples
      Involvement of Lysophosphatidic acid receptor 4 (LPAR4)- dependent signaling in direct cardiac reprogramming

      P.B14 • Michela Buonaiuto • Naples
      A novel combination of drugs restrains glioblastoma growth in vitro and in vivo

      P.B16 • Francesco Capradossi • Rome
      5-lipoxygenase mediates etoposide-induced cancer repopulation and acquired cell-resistance (CRAC) in castration resistant prostate cancer cells

      P.B18 • Claudia Carsetti • Rome
      Cullin-4 inhibition works as a spastin-elevating approach in preclinical models of hereditary spastic paraplegia

      P.B20 • Mariangela Cavallaro • Fisciano (SA)
      Identifying epigenetic changes linked to activation of TBX1

      P.B22 • Francesca Corsi • Rome
      Cerium oxide nanozymes prevent prostate cancer relapse and progression by dismantling therapy-induced inflammatory COX-2/5-LOX lipid signalling

      P.B24 • Elisa Costanzo • Palermo
      Developing liver spheroids as a model to investigate the role of colorectal-cancer derived small extracellular vesicles in metastatic niche establishment

      P.B26 • Federico Donà • Milan
      Tissue specific mechanisms maintain epithelial integrity upon division misorientation

      P.B28 • Carlotta Duval • Turin
      Reciprocal screens ensure the identification of an epigenetic network for epithelial stem cell plasticity

      P.B30 • Amir Fardin • Milan
      The in vivo characterization of EPSIN 3 in breast cancer tumorigenesis and metastasis

      P.B32 • Marco Fiocchetti • Rome
      Functional role of the neuroprotective protein neuroglobin on differentiation and morphological phenotype of human neurons

      P.B34 • Silvia Graziani • Padua
      De novo mitochondrial DNA synthesis in senescent endothelial cells sustains sterile inflammation and doxorubicin cardiotoxicity

      P.B36 • Alessia Iaiza • Rome
      Role of m6A-dependent circRNAs during stress response in myeloid leukemia cells

      P.B38 • Gaia Laurenzi • Rome
      The role of protein-kinase C theta (PKCθ) in ALS disease progression

      P.B40 • Giorgia Lombardozzi • L'Aquila
      Protective effect of NGF in the diabetic retinopathy

      P.B42 • Andrea Lunardi • Trento
      Fire up innate immunity in prostate cancer

      P.B44 • Vanessa Medici • Rome
      Evaluation of the combined inhibition of alternative splicing and EZH2 activity as pro-immunogenic treatment for triple-negative breast cancers

      P.B46 • Sonia Missiroli • Ferrara
      PML at MAMs orchestrates signaling pathways IN- and OUT-side tumors

      P.B48 • Giampaolo Morciano • Ferrara
      A naturally occurring mutation in ATP synthase subunit c is associated with increased damage following hypoxia/reoxygenation in STEMI patients

      P.B50 • Alyssa Paganoni • Milan
      The Rho GTPases effector Rhotekin drives cytoskeletal dynamics tuning cortical development

      P.B52 • Claudia Palazzo • Rome
      Exosomes released by tumor cells mediate a new neuropilin-dependent mechanism of endothelial cell regulation

      P.B54 • Silvia Piscitelli • Naples
      The RNA-binding protein Lin28a orchestrates ESCs fate by changing partners during differentiation

      P.B56 • Luca Ponzone • Turin
      Rictor/mTORC2 downregulation promotes metabolic rewiring and therapeutic resistance in BRAFV600E melanoma cells

      P.B58 • Maria serena Roca • Naples
      Valproic Acid sensitizes colorectal cancer to chemotherapy by targeting cancer stem cell compartment through β-Catenin modulation

      P.B60 • Federica Saracino • Naples
      Dissecting the mechanisms underlying symmetry breaking and tissue-scale organization in colorectal cancer organoids

      P.B62 • Francesca Spinelli • Padua
      The role of mitochondrial cations homeostasis in the control of the inflammatory response

      P.B64 • Claudia Tito • Rome
      The role of Sorcin in the EGF-dependent EGFR signaling pathways in lung branching development and cancer

      P.B66 • Marta Urbani • Rome
      Modelling chemotherapy-induced Cancer Repopulation and Acquired Cell-resistance in prostate cells

      P.C2 • Virginia Campani • Modena
      The NF–Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer

      P.C4 • Claudia Cirotti • Rome
      NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma

      P.C6 • Giacomo Corleone • Rome
      Uncovering the Role of NRF1/BRD3 axis as key mediators of Multiple Myeloma Progression

      P.C8 • Antonello Cutolo • Naples
      The CNOS center of nanophotonics for human health and a new teranostic platform: the hospital in the needle

      P.C10 • Greta Deidda Tarquini • Rome
      Cerium oxide nanoparticles protect human keratinocytes from UV-induced cell damage and oxidative stress and prevent mutagenesis

      P.C12 • Ozlem Kartal • Padua
      Targeting mitochondrial calcium and metabolism by RNA-based therapy in sarcopenia

      P.C14 • Adriana Limone • Naples
      Activation of non-canonical autophagic pathway through RPSA inhibition in neuronal cells: implications for neurodegenerative diseases

      P.C16 • Sandro Montefusco • Pozzuoli
      The TIGEM High Content Screening facility: Integrating advance technologies for investigating and treat genetic diseases

      P.C18 • Lorena Musco • Aviano
      Investigating the molecular diversity of luminal breast cancer arising in young women

      P.C20 • Sabela Nikolli • Rome
      Variations in the expression of DNA repair genes and in the expression of genes involved in oxidative stress used as biomarkers to identify the exposure to heavy metals

      P.C22 • Monica Pastorino • Naples
      The pesticide chlorpyrifos affects Npy and Agrp expression both in vivo and in vitro

      P.C24 • Martina Scano • Padua
      Repurposing CFTR correctors in Allan Herndon Dudley syndrome

      P.C26 • Vanessa Tolotto • Udine
      HDAC4 targeting in FBXW7 mutated CRC re-sensitizes cells to Oxaliplatin treatment